INTRODUCTION

Skin appearance and texture are strictly dependent on the proper biosynthesis of biomolecules by fibroblasts. These cells continuously renovate the matrix surrounding the dermal cell population by orchestrating the synthesis of collagen and elastin. As a result, they support the structural integrity and elasticity of the skin.

The biosynthetic machinery is activated mainly by certain proteins, among which growth factors play a key role. However, ageing and environmental factors can compromise fibroblast function, creating a need for interventions that restore their regenerative capabilities.

The ACTV8SKN™ Actuator, powered by SIGMOLECS peptides—synthesized to mimic human growth factors—was developed to promote renovation pathways and counteract ageing processes.

This research investigated the impact of the Actuator on the signalling pathways governing COL1A1 and ELN cellular expression, as well as its efficacy in improving skin appearance, in comparison with a growth factor-enriched competitor product (CP).

Home Use – morning and evening or as needed especially after laser.
Gently apply a few drops of the Actuator to your cleansed face. Lightly spread the drops to cover the desired area with a thin layer.
The fluid gel will absorb as soon as it is spread.

INGREDIENTS

SIGMOLECS®
SH-oligopeptide-1
• SIGMOLECS®
SH-oligopeptide-2
• SIGMOLECS®
SH-polypeptide-1
• SIGMOLECS®
SH-polypeptide-42

Indications

Pre i posle procedure – laser, mikronidling, hemijski piling, PRP, fileri.

Patient benefits

More elastic, bright and hydrated skin. Protection from environmental stress. Sustains regenerative treatments between appointments and as a regular anti-aging plan.